She hosted the first episode of the reality TV show On the Lot, but quit before the second episode aired, saying later that she left, "Because I smelled the disaster happening before it did." The show, produced by Steven Spielberg and Mark Burnett, was a competition for aspiring filmmakers vying for a chance at stardom. Handler was replaced by former Robin & Company entertainment anchor, Adrianna Costa.
In April 2006, Handler began hosting The Chelsea Handler Show on E! In 2007, Handler performed with Comedy Central's Hour Stand-Up Comedy Tour across the United States.
network from 2007 to 2014, and released a documentary series, Chelsea Does, on Netflix in January 2016. Other shows on which Handler has appeared include Weekends at the D.
In 2016, Handler filmed a documentary series for Netflix titled Chelsea Does, consisting of four episodes on marriage, Silicon Valley, racism, and drugs.
In February 2015, Handler said she envisioned a show more serious than Chelsea Lately.
The same year, a leaked sex tape of Handler was being offered for sale.
After news of it became public, Handler said on Chelsea Lately the tape "was made as a joke" more than 10 years earlier, adding, "I put it on an audition tape for a comedy club, because I'm a comedienne, and I've been showing it at birthday parties for fucking years." In a 2011 interview in The New York Times, Handler revealed that she had an abortion when she was 16, saying she had the procedure "because that's what I should have done. Anyway, those are things that people shouldn't be dishonest about." Handler was a vocal supporter of the 2016 presidential candidate Hillary Clinton and was critical of her opponent Donald Trump.
On May 11, 2012, the network canceled it after only one season.
Laura Prepon played the main character Chelsea Newman, a cocktail waitress while Handler portrayed Chelsea's born-again Christian sister Sloane, a married, conservative, new mom who had little in common with her carefree sister.
"I would like a healthy mix of everything that goes on around the world, mixed with interesting stuff in our country.
The well-roundedness of 60 Minutes but faster, quicker, cooler." Handler has authored five books that have made the New York Times Best Seller List, four of which have reached number one.
Her first book, My Horizontal Life: A Collection of One-Night Stands (2005), describes the variety of sexual encounters she has experienced throughout her life. It's Me, Chelsea (2008), a collection of humorous essays, hit the top of The New York Times Nonfiction Best Seller List on May 11, 2008, On November 15, 2010, it was announced that Handler's publishers gave her her own publishing imprint, Borderline Amazing/A Chelsea Handler Book.